Ed higher background signals on non-tumor tissues, the activatable PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/14960617 probe was highly promising to significantly enhance imaging contrast and reduce diagnosis time [55].
Simultaneous detection of various cancer cell types is another useful application of aptamer biosensors. This was achieved previously through optical means in vitro, by labeling the different 6-Fluoroquinaldine cancer cells with distinct aptamer-conjugated fluorescent NPs. Kang et al. conjugated three aptamers: AS1411 (targeting nucleolin), TTA1 (for tenascin-C), and MUC-1 (for mucin) with three QDs of […]
